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Immunol Lett. 2006 Apr 15;104(1-2):38-45. Epub 2005 Dec 1.

How antibodies act as natural adjuvants.

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  • 1Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.


Antibodies can act like adjuvants. They can potently enhance the antibody response, and in the case of IgG and IgE also the T cell response, to the very antigen they are specific for. In this review we will discuss the recent advances made in our understanding of the underlying mechanisms of antibody-mediated feedback enhancement. The immuno-stimulatory properties of IgM, IgG1, IgG2a, IgG2b, IgG3 and IgE will be reviewed in relationship to the complement system and Fc receptors and the physiological relevance will be discussed.

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