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J Muscle Res Cell Motil. 2006;27(2):125-37. Epub 2005 Dec 17.

Interaction of kinesin motors, microtubules, and MAPs.

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  • 1Max-Planck-Unit for Structural Molecular Biology, Notkestrasse 85, 22607, Hamburg, Germany.


Kinesins are a family of microtubule-dependent motor proteins that carry cargoes such as vesicles, organelles, or protein complexes along microtubules. Here we summarize structural studies of the "conventional" motor protein kinesin-1 and its interactions with microtubules, as determined by X-ray crystallography and cryo-electron microscopy. In particular, we consider the docking between the kinesin motor domain and tubulin subunits and summarize the evidence that kinesin binds mainly to beta tubulin with the switch-2 helix close to the intradimer interface between alpha and beta tubulin.

[PubMed - indexed for MEDLINE]
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