Crick-Jacobs Center for Computational and Theoretical Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. geneyeo@salk.edu
Silencing of splicing regulators by RNA interference, combined with splicing-specific microarrays, has revealed a complex network of distinct alternative splicing events in Drosophila, while a high-throughput screen of more than 6,000 compounds has identified drugs that interfere specifically and directly with one class of splicing regulators in human cells.