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Genome Biol. 2005;6(12):240. Epub 2005 Dec 1.

Splicing regulators: targets and drugs.

Author information

  • Crick-Jacobs Center for Computational and Theoretical Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. geneyeo@salk.edu

Abstract

Silencing of splicing regulators by RNA interference, combined with splicing-specific microarrays, has revealed a complex network of distinct alternative splicing events in Drosophila, while a high-throughput screen of more than 6,000 compounds has identified drugs that interfere specifically and directly with one class of splicing regulators in human cells.

PMID:
16356274
[PubMed - indexed for MEDLINE]
PMCID:
PMC1414078
Free PMC Article

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