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Genome Biol. 2005;6(12):R105. Epub 2005 Dec 2.

A low-cost open-source SNP genotyping platform for association mapping applications.

Author information

  • 1Department of Ecology and Evolutionary Biology, University of California Irvine, CA 92697-2525, USA. sjm@uci.edu

Abstract

Association mapping aimed at identifying DNA polymorphisms that contribute to variation in complex traits entails genotyping a large number of single-nucleotide polymorphisms (SNPs) in a very large panel of individuals. Few technologies, however, provide inexpensive high-throughput genotyping. Here, we present an efficient approach developed specifically for genotyping large fixed panels of diploid individuals. The cost-effective, open-source nature of our methodology may make it particularly attractive to those working in nonmodel systems.

PMID:
16356268
[PubMed - indexed for MEDLINE]
PMCID:
PMC1414086
Free PMC Article

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