J Clin Pharmacol. 1992 Jun;32(6):536-8.

Cholestyramine-induced hyperchloremic metabolic acidosis.

Scheel PJ Jr, Whelton A, Rossiter K, Watson A.

Source

Division of Nephrology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205.

Abstract

Cholestyramine is a nonabsorbable anion exchange resin that is used predominantly for the treatment of hypercholesterolemia in adults and the management of acute diarrhea in children. The authors report two cases of severe hyperchloremic nonanion gap metabolic acidosis associated with the use of cholestyramine therapy. The authors recommend that patients taking cholestyramine who have concomitant renal insufficiency or who are volume depleted or who are taking spironolactone be monitored carefully for the emergence of a hyperchloremic metabolic acidosis.

PMID:: 1634640; [PubMed - indexed for MEDLINE]

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