Catheter Cardiovasc Interv. 2006 Jan;67(1):139-41.

Intra-atrial tissue plasminogen activator infusion for prosthetic valve thrombosis.

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Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.

Abstract

Thrombosis is a well-known and life-threatening complication of prosthetic mechanical valves. Therapy typically requires medical thrombolysis or surgical thrombectomy/valve replacement. We report the case of a thrombosed atrioventricular valve in a young boy with complex congenital heart disease, which was successfully treated with direct intra-atrial infusion of recombinant tissue plasminogen activator after failed attempts at systemic therapy. We present this treatment as an alternative to conventional medical therapy.

PMID:: 16345053; [PubMed - indexed for MEDLINE]

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[Thrombolysis of prosthetic heart valve thrombosis using recombinant tissue plasminogen activator (rt-PA) in infancy and childhood]. [Z Kardiol. 2001]
[Thrombolysis of prosthetic heart valve thrombosis using recombinant tissue plasminogen activator (rt-PA) in infancy and childhood].
Serpi M, Schmidt KG, Kreuz W, Bucsenez D, Springer W, Hagl S, Ulmer HE. Z Kardiol. 2001 Mar; 90(3):191-6.
Intravenous thrombolytic treatment of mechanical prosthetic valve thrombosis: a study using serial transesophageal echocardiography. [J Am Coll Cardiol. 2000]
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Ozkan M, Kaymaz C, Kirma C, Sönmez K, Ozdemir N, Balkanay M, Yakut C, Deligönül U. J Am Coll Cardiol. 2000 Jun; 35(7):1881-9.
Use of transesophageal echocardiography during thrombolysis with tissue plasminogen activator of a thrombosed prosthetic mitral valve. [J Am Soc Echocardiogr. 1992]
Use of transesophageal echocardiography during thrombolysis with tissue plasminogen activator of a thrombosed prosthetic mitral valve.
Young E, Shapiro SM, French WJ, Ginzton LE. J Am Soc Echocardiogr. 1992 Mar-Apr; 5(2):153-8.
Review [Treatment alternatives in mechanical valve thrombosis]. [Turk Kardiyol Dern Ars. 2008]
Review [Treatment alternatives in mechanical valve thrombosis].
Duran NE, Biteker M, Ozkan M. Turk Kardiyol Dern Ars. 2008 Sep; 36(6):420-5.
Review Prosthetic valve thrombosis and thrombolysis: a case report and review of the literature. [Am J Med Sci. 2001]
Review Prosthetic valve thrombosis and thrombolysis: a case report and review of the literature.
Tsiouris N, Ahmad M. Am J Med Sci. 2001 Oct; 322(4):229-32.

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