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BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study.
Karamohamed S,
Latourelle JC,
Racette BA,
Perlmutter JS,
Wooten GF,
Lew M,
Klein C,
Shill H,
Golbe LI,
Mark MH,
Guttman M,
Nicholson G,
Wilk JB,
Saint-Hilaire M,
DeStefano AL,
Prakash R,
Tobin S,
Williamson J,
Suchowersky O,
Labell N,
Growdon BN,
Singer C,
Watts R,
Goldwurm S,
Pezzoli G,
Baker KB,
Giroux ML,
Pramstaller PP,
Burn DJ,
Chinnery P,
Sherman S,
Vieregge P,
Litvan I,
Gusella JF,
Myers RH,
Parsian A.
Department of Neurology, Boston University School of Medicine, MA, USA.
Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
PMID: 16344533 [PubMed - indexed for MEDLINE]
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