Send to:

Choose Destination
See comment in PubMed Commons below
Genesis. 2005 Dec;43(4):196-204.

Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis.

Author information

  • 1Laboratory of Developmental Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.


Recent studies show that the cyclic expression of Lfng in the presomitic mesoderm (PSM) is controlled at the transcription level by Notch signal through the CBF1 binding site for activation and periodic repression on the Lfng promoter. Here we provide genetic evidence that the oscillatory expression is controlled by a negative feedback mechanism. We also show that Hes7, another cyclically expressed protein, can bind to the N-boxes on both Lfng and its own promoters and repress their activity. In addition, we demonstrate that the 3' untranslated region (3'-UTR) is important for rapid degradation of Lfng mRNA.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk