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1: FEBS Lett. 1992 Jul 20;306(2-3):169-72.Click here to read Links

Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte.

Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP.

Notre-Dame Hospital Research Centre, Department of Medicine, University of Montreal, Qué., Canada.

Normal and osteoarthritic (OA) human articular cartilage chondrocytes, released enzymatically in the presence of 0.5% fetal calf serum, display constitutive expression of early response activating protein (AP-1) genes; c-fos, c-jun and jun-B. Among the late AP-1 responsive genes, total metallothionein (MT) and stromelysin mRNAs were expressed at high levels in both normal and OA chondrocytes, while collagenase and hMT-IIA mRNA levels were elevated only in OA individuals. Despite the common AP-1 sequences present in their promoter regions, the three late genes were differentially expressed.

PMID: 1633872 [PubMed - indexed for MEDLINE]