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FEBS Lett. 2006 Feb 13;580(4):1017-22. Epub 2005 Dec 1.

Membrane topology of human ABC proteins.

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  • 1Institute of Enzymology, Hungarian Academy of Sciences, Karolina út 29, 1113 Budapest, Hungary.


In this review, we summarize the currently available information on the membrane topology of some key members of the human ABC protein subfamilies, and present the predicted domain arrangements. In the lack of high-resolution structures for eukaryotic ABC transporters this topology is based only on prediction algorithms and biochemical data for the location of various segments of the polypeptide chain, relative to the membrane. We suggest that topology models generated by the available prediction methods should only be used as guidelines to provide a basis of experimental strategies for the elucidation of the membrane topology.

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