FEBS Lett. 2005 Dec 19;579(30):6885-9.

Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma.

Flygare J, Gustafsson K, Kimby E, Christensson B, Sander B.

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Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Karolinska University Hospital Huddinge, F-46, SE-141 86 Stockholm, Sweden.

Abstract

We have earlier reported overexpression of the central and peripheral cannabinoid receptors CB1 and CB2 in mantle cell lymphoma (MCL), a B cell non-Hodgkin lymphoma. In this study, treatment with cannabinoid receptor ligands caused a decrease in viability of MCL cells, while control cells lacking CB1 were not affected. Interestingly, equipotent doses of the CB1 antagonist SR141716A and the CB1/CB2 agonist anandamide inflicted additive negative effects on viability. Moreover, treatment with the CB1/CB2 agonist Win-55,212-2 caused a decrease in long-term growth of MCL cells in culture. Induction of apoptosis, as measured by FACS/Annexin V-FITC, contributed to the growth suppressive effect of Win-55,212-2. Our data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL.

PMID:: 16337199; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells. [Cell Death Dis. 2011]
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