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Cell Immunol. 2005 Sep;237(1):68-75. Epub 2005 Dec 6.

Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.

Author information

  • 1Department of Immunology, University of Connecticut, School of Medicine, Farmington, CT, USA.

Abstract

OBJECTIVE:

Bromelain, a clinically used pineapple extract and natural product, has reported anti-inflammatory and immunomodulatory activities. The purpose of this study was to determine the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).

METHODS:

To establish AAD, mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols. Mice were treated i.p. with either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days. Bronchoalveolar lavage leukocytes and cytokines, lung histology, airway hyperresponsiveness, and lymphocyte populations via flow cytometry were compared between groups.

RESULTS:

Bromelain treatment of AAD mice resulted in reduced total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.

CONCLUSION:

Bromelain attenuated development of AAD while altering CD4+ to CD8+ T lymphocyte populations. The reduction in AAD outcomes suggests that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders.

PMID:
16337164
[PubMed - indexed for MEDLINE]
PMCID:
PMC2576519
Free PMC Article

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