Design and synthesis of 2'-anilino-4,4'-bipyridine...[Bioorg Med Chem Lett. 2006]

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1: Bioorg Med Chem Lett. 2006 Mar 1;16(5):1397-401. Epub 2005 Dec 5. Links

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.

Swahn BM, Xue Y, Arzel E, Kallin E, Magnus A, Plobeck N, Viklund J.

Department of Medicinal Chemistry, AstraZeneca R&D Södertälje, S-151 85, Södertälje, Sweden. britt-marie.swahn@astrazeneca.com

The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.

PMID: 16337120 [PubMed - indexed for MEDLINE]

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Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.

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