Biol Chem. 2005 Dec;386(12):1265-71.

Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements.

Source

Institut für Biochemie, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany.

Abstract

Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct protein products. This is accomplished by the differential recognition of splice sites in the pre-mRNA, often regulated in a tissue- or development-specific manner. Alternative splicing constitutes not only an important mechanism in controlling gene expression in humans, but also an essential source for increasing proteome diversity. In this review we summarize the underlying mechanistic principles, focussing on the cis-acting regulatory elements. In particular, the role of short sequence repeats, which are often polymorphic, in splicing regulation is discussed.

PMID:: 16336120; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Alternative pre-mRNA splicing and proteome expansion in metazoans. [Nature. 2002]
Review Alternative pre-mRNA splicing and proteome expansion in metazoans.
Maniatis T, Tasic B. Nature. 2002 Jul 11; 418(6894):236-43.
Review Regulation of mammalian pre-mRNA splicing. [Sci China C Life Sci. 2009]
Review Regulation of mammalian pre-mRNA splicing.
Hui J. Sci China C Life Sci. 2009 Mar; 52(3):253-60. Epub 2009 Mar 18.
Review Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA. [Prog Nucleic Acid Res Mol Biol...]
Review Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA.
Bourgeois CF, Lejeune F, Stévenin J. Prog Nucleic Acid Res Mol Biol. 2004; 78:37-88.
Review Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation. [Annu Rev Genet. 1998]
Review Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation.
Lopez AJ. Annu Rev Genet. 1998; 32:279-305.
Control of alternative pre-mRNA splicing by distributed pentameric repeats. [Proc Natl Acad Sci U S A. 1997]
Control of alternative pre-mRNA splicing by distributed pentameric repeats.
Hedjran F, Yeakley JM, Huh GS, Hynes RO, Rosenfeld MG. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12343-7.

See reviews... See all...

Cited by 7 PubMed Central articles

Review Post-transcriptional regulation in lymphocytes: the case of CD154. [RNA Biol. 2009]
Review Post-transcriptional regulation in lymphocytes: the case of CD154.
Vavassori S, Covey LR. RNA Biol. 2009 Jul-Aug; 6(3):259-65. Epub 2009 Jul 29.
Proteomics studies confirm the presence of alternative protein isoforms on a large scale. [Genome Biol. 2008]
Proteomics studies confirm the presence of alternative protein isoforms on a large scale.
Tress ML, Bodenmiller B, Aebersold R, Valencia A. Genome Biol. 2008; 9(11):R162. Epub 2008 Nov 18.
Review Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. [Endocr Rev. 2008]
Review Clinical, agricultural, and evolutionary biology of myostatin: a comparative review.
Rodgers BD, Garikipati DK. Endocr Rev. 2008 Aug; 29(5):513-34. Epub 2008 Jun 30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Alternative pre-mRNA splicing in the human system: unexpected role of repetitive...
Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements.
Biol Chem. 2005 Dec ;386(12):1265-71.

PubMed
Conserved and variable functions of the sigmaE stress response in related genome...
Conserved and variable functions of the sigmaE stress response in related genomes.
PLoS Biol. 2006 Jan ;4(1):e2.

PubMed
Identification of Drosophila gene products required for phagocytosis of Candida ...
Identification of Drosophila gene products required for phagocytosis of Candida albicans.
PLoS Biol. 2006 Jan ;4(1):e4. Epub 2005 Dec 20 .

PubMed
Sleep and aging: prevalence of disturbed sleep and treatment considerations in o...
Sleep and aging: prevalence of disturbed sleep and treatment considerations in older adults.
J Clin Psychiatry. 2005 ;66 Suppl 9:24-30; quiz 42-3.

PubMed
VEMS 3.0: algorithms and computational tools for tandem mass spectrometry based ...
VEMS 3.0: algorithms and computational tools for tandem mass spectrometry based identification of post-translational modifications in proteins.
J Proteome Res. 2005 Nov-Dec ;4(6):2338-47.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: