Appl Microbiol Biotechnol. 2006 Jan;69(5):493-8. Epub 2005 Dec 7.

Microbiology and biochemistry of nicotine degradation.

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Institut für Biochemie und Molekularbiologie, Hermann-Herder-Str. 7, 79104, Freiburg, Germany. roderich.brandsch@biochemie.uni-freiburg.de

Abstract

Several bacterial species are adapted to nicotine, the main alkaloid produced by the tobacco plant, as growth substrate. A general outline of nicotine catabolism by these bacteria is presented, followed by an emphasis on new insights based on molecular biology and biochemical work obtained with the catabolic plasmid pAO1 of Arthrobacter nicotinovorans. Its 165-kb sequence revealed the genetic structure of nicotine catabolism and allowed the assignment of new enzyme activities to specific gene products, which extends the known biochemical steps of this pathway. Potential implications of the progress in our understanding of bacterial breakdown of nicotine for biotechnological applications are discussed.

PMID:: 16333621; [PubMed - indexed for MEDLINE]

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Nicotine

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Cited by 5 PubMed Central articles

Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation. [Sci Rep. 2012]
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Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16. [Appl Environ Microbiol. 2009]
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Tang H, Wang L, Meng X, Ma L, Wang S, He X, Wu G, Xu P. Appl Environ Microbiol. 2009 Feb; 75(3):772-8. Epub 2008 Dec 5.
A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16. [Appl Environ Microbiol. 2008]
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