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Br J Clin Pharmacol. 1992 Jul;34(1):60-4.

Enhancement of the oral absorption of cyclosporin in man.

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  • 1Department of Anesthesia and Research, University of Basel, Switzerland.


1. The oral absorption of cyclosporin from three new semi-solid oral formulations was compared with the standard soft gelatine preparation in twelve healthy male volunteers. One formulation was based on a solid micellar solution, while the other two, with different in vitro release properties, were based on a microemulsion principle. 2. The results showed that the solid micellar solution and the faster releasing microemulsion formulation increased the extent of absorption on average by 45.2 and 49.0%, respectively, compared with the reference soft gelatine capsule.

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