Trends Neurosci. 2006 Feb;29(2):108-15. Epub 2005 Dec 5.

Mechanisms of rhythmogenesis: insights from hypothalamic vasopressin neurons.

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Centre for Neuroendocrinology and Department of Physiology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand. colin.brown@stonebow.otago.ac.nz

Abstract

Many neurons in the CNS, including hypothalamic vasopressin-expressing cells, display rhythmic activity patterning. These vasopressin neurons receive random synaptic input but fire action potentials in alternating periods of activity and silence that each lasts tens of seconds. Recent work demonstrates that vasopressin cell rhythmicity depends on feedback modulation of intrinsic membrane properties and synaptic inputs by peptides released from the dendrites of these neurons. Many other neurons across the CNS release neurotransmitters from their dendrites; therefore, vasopressin cells provide an insight into the potential mechanisms that support neuronal activity patterning across the CNS.

PMID:: 16330104; [PubMed - indexed for MEDLINE]

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Review Rhythmogenesis in vasopressin cells. [J Neuroendocrinol. 2004]
Review Rhythmogenesis in vasopressin cells.
Brown CH. J Neuroendocrinol. 2004 Sep; 16(9):727-39.
Review Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons. [Prog Brain Res. 2008]
Review Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons.
Brown CH, Ruan M, Scott V, Tobin VA, Ludwig M. Prog Brain Res. 2008; 170:219-28.
The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somatodendritic Peptide release. [Endocrinology. 2008]
The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somatodendritic Peptide release.
Tobin VA, Bull PM, Arunachalam S, O'Carroll AM, Ueta Y, Ludwig M. Endocrinology. 2008 Dec; 149(12):6136-45. Epub 2008 Aug 14.
Temporal dissociation of the feedback effects of dendritically co-released peptides on rhythmogenesis in vasopressin cells. [Neuroscience. 2004]
Temporal dissociation of the feedback effects of dendritically co-released peptides on rhythmogenesis in vasopressin cells.
Brown CH, Ludwig M, Leng G. Neuroscience. 2004; 124(1):105-11.
A study of ionic conductances involved in plateau potential activity in putative vasopressinergic neurons in primary cell culture. [Brain Res. 1988]
A study of ionic conductances involved in plateau potential activity in putative vasopressinergic neurons in primary cell culture.
Legendre P, Poulain DA, Vincent JD. Brain Res. 1988 Aug 9; 457(2):386-91.

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Cited by 2 PubMed Central articles

Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity. [J Physiol. 2009]
Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity.
Scott V, Bishop VR, Leng G, Brown CH. J Physiol. 2009 Dec 1; 587(Pt 23):5679-89. Epub 2009 Oct 12.
Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization. [J Physiol. 2009]
Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization.
Ruan M, Brown CH. J Physiol. 2009 Mar 1; 587(Pt 5):1043-56. Epub 2009 Jan 12.

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