J Neural Transm Gen Sect. 1992;88(2):157-60.

The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer.

Hyttel J, Bøgesø KP, Perregaard J, Sánchez C.

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H. Lundbeck A/S, Research & Development, Copenhagen, Denmark.

Abstract

The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers*) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N-demethylcitalopram very much resembles the profile of the respective racemates.

PMID:: 1632943; [PubMed - indexed for MEDLINE]

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