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Otolaryngol Clin North Am. 2005 Dec;38(6):1193-201, viii.

Bacterial biofilms: do they play a role in chronic sinusitis?

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  • 1Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, 5 Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.


Although medical and surgical strategies for chronic sinusitis have been greatly refined during the last 2 decades, many patients continue to suffer. Bacterial biofilms are three-dimensional aggregates of bacteria that recently have been shown to play a major role in many chronic infections. There is growing evidence that bacterial biofilms may play a role in some forms of recalcitrant chronic sinusitis that persists despite surgically opened sinus cavities and what seems to be appropriate, culture-directed antibiotic therapy. New directions in therapy aimed at biofilms may provide some success in treatment for patients with chronic sinusitis.

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