J Neuroimmunol. 2006 Mar;172(1-2):9-17. Epub 2005 Dec 2.

Acute morphine exposure potentiates the development of HSV-1-induced encephalitis.

Lioy DT, Sheridan PA, Hurley SD, Walton JR, Martin AM, Olschowka JA, Moynihan JA.

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Department of Microbiology and Immunology, 575 Elmwood Ave., University of Rochester, Rochester, NY 14621, United States.

Abstract

A devastating consequence of HSV-1 infection is development of HSV-1-induced encephalitis (HSVE). While only a minority of individuals infected with HSV-1 experiences HSVE, clearly defined variables that consistently predict development of the disease remain to be elucidated. The current study examined the effects of a single dose of morphine prior to infection with HSV-1 on the development of HSVE in BALB/cByJ mice. Acute morphine exposure was observed to potentiate the development of HSVE in HSV-1 infected mice. The present data implicate a potential role for the blood-brain barrier in the development of HSVE in morphine-treated mice.

PMID:: 16325924; [PubMed - indexed for MEDLINE]

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1R01 AI48361/AI/NIAID NIH HHS/United States

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Chemical compound information

Morphine

MW: 285.33 g/mol

MF: C₁₇H₁₉NO₃

See 8 citations for this compound....

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