Trends Cell Biol. 2006 Jan;16(1):36-44. Epub 2005 Dec 1.

Regulation of skeletal muscle gene expression by p38 MAP kinases.

Lluís F, Perdiguero E, Nebreda AR, Muñoz-Cánoves P.

Source

Center for Genomic Regulation (CRG), Program on Differentiation and Cancer, Barcelona, Spain.

Abstract

The formation of skeletal muscle is a multistep process orchestrated by the basic helix-loop-helix myogenic regulatory factors (MRFs). A wide array of proteins can interact with the MRFs, resulting in either induction or repression of their myogenic potential and subsequent MRF-mediated muscle-specific transcription. Findings published over the past few years have unambiguously established a key role for the p38 MAP kinase pathway in the control of muscle gene expression at different stages of the myogenic process. Here, we discuss the mechanisms by which p38 MAP kinase controls skeletal muscle differentiation by regulating the sequential activation of MRFs and their transcriptional coactivators, including chromatin remodeling enzymes.

PMID:: 16325404; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Phosphorylation of MRF4 transactivation domain by p38 mediates repression of specific myogenic genes. [EMBO J. 2004]
Phosphorylation of MRF4 transactivation domain by p38 mediates repression of specific myogenic genes.
Suelves M, Lluís F, Ruiz V, Nebreda AR, Muñoz-Cánoves P. EMBO J. 2004 Jan 28; 23(2):365-75. Epub 2004 Jan 22.
Review The p38 MAPK signaling pathway: a major regulator of skeletal muscle development. [Mol Cell Endocrinol. 2006]
Review The p38 MAPK signaling pathway: a major regulator of skeletal muscle development.
Keren A, Tamir Y, Bengal E. Mol Cell Endocrinol. 2006 Jun 27; 252(1-2):224-30. Epub 2006 Apr 27.
Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. [Mol Cell Biol. 2009]
Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.
Dacwag CS, Bedford MT, Sif S, Imbalzano AN. Mol Cell Biol. 2009 Apr; 29(7):1909-21. Epub 2009 Feb 2.
PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways. [Cell Signal. 2008]
PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways.
Alisi A, Spaziani A, Anticoli S, Ghidinelli M, Balsano C. Cell Signal. 2008 Mar; 20(3):534-42. Epub 2007 Nov 26.
Review Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications. [J Cell Physiol. 2000]
Review Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications.
Puri PL, Sartorelli V. J Cell Physiol. 2000 Nov; 185(2):155-73.

See reviews... See all...

Cited by 41 PubMed Central articles

Elongating under Stress. [Genet Res Int. 2011]
Elongating under Stress.
de Nadal E, Posas F. Genet Res Int. 2011; 2011:326286. Epub 2011 Sep 7.
TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and Akt pathways. [PLoS One. 2012]
TRAF6 promotes myogenic differentiation via the TAK1/p38 mitogen-activated protein kinase and Akt pathways.
Xiao F, Wang H, Fu X, Li Y, Wu Z. PLoS One. 2012; 7(4):e34081. Epub 2012 Apr 4.
A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts. [Skelet Muscle. 2012]
A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts.
Knight JD, Tian R, Lee RE, Wang F, Beauvais A, Zou H, Megeney LA, Gingras AC, Pawson T, Figeys D, et al. Skelet Muscle. 2012 Mar 6; 2:5. Epub 2012 Mar 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulation of skeletal muscle gene expression by p38 MAP kinases.
Regulation of skeletal muscle gene expression by p38 MAP kinases.
Trends Cell Biol. 2006 Jan ;16(1):36-44. Epub 2005 Dec 1 .

PubMed
Antileishmanial and trypanocidal activities of new miltefosine liposomal formula...
Antileishmanial and trypanocidal activities of new miltefosine liposomal formulations.
Biomed Pharmacother. 2005 Dec ;59(10):545-50. Epub 2005 Oct 21 .

PubMed
[Escherichia coli thyroid abscess associated with multinodular goitre].
[Escherichia coli thyroid abscess associated with multinodular goitre].
Rev Med Interne. 2006 Mar ;27(3):258-60. Epub 2005 Nov 22 .

PubMed
Prediction of protease types in a hybridization space.
Prediction of protease types in a hybridization space.
Biochem Biophys Res Commun. 2006 Jan 20 ;339(3):1015-20. Epub 2005 Nov 9 .

PubMed
Nonpleural mesotheliomas: mesothelioma of the peritoneum, tunica vaginalis, and ...
Nonpleural mesotheliomas: mesothelioma of the peritoneum, tunica vaginalis, and pericardium.
Hematol Oncol Clin North Am. 2005 Dec ;19(6):1067-87, vi.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: