Structure and function of the platelet integrin al...[J Clin Invest. 2005]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 1

Click to change filter selection through MyNCBI.

1: J Clin Invest. 2005 Dec;115(12):3363-9. Links

Structure and function of the platelet integrin alphaIIbbeta3.

Bennett JS.

Hematology-Oncology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6058, USA. bennetts@mail.med.upenn.edu

The platelet integrin alpha(IIb)beta(3) is required for platelet aggregation. Like other integrins, alpha(IIb)beta(3) resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of the alpha(IIb) and beta(3) transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.

PMID: 16322781 [PubMed - indexed for MEDLINE]

PMCID: PMC1297263

Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3.
J Biol Chem. 2004 Jun 4; 279(23):24624-30. Epub 2004 Mar 30.

[J Biol Chem. 2004]
Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography.
Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14059-64. Epub 2002 Oct 18.

[Proc Natl Acad Sci U S A. 2002]
ReviewClues for understanding the structure and function of a prototypic human integrin: the platelet glycoprotein IIb/IIIa complex.
Thromb Haemost. 1994 Jul; 72(1):1-15.

[Thromb Haemost. 1994]
Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):5878-83.

[Proc Natl Acad Sci U S A. 2002]
ReviewPlatelet integrin alpha(IIb)beta(3): activation mechanisms.
J Thromb Haemost. 2007 Jul; 5(7):1345-52.

[J Thromb Haemost. 2007]
» See reviews... | » See all...

Cited by 5 PubMed Central articles

Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families.
Gresele P, Falcinelli E, Giannini S, D'Adamo P, D'Eustacchio A, Corazzi T, Mezzasoma AM, Di Bari F, Guglielmini G, Cecchetti L, et al. Haematologica. 2009 May; 94(5):663-9. Epub 2009 Mar 31.

[Haematologica. 2009]
Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity.
Millon-Frémillon A, Bouvard D, Grichine A, Manet-Dupé S, Block MR, Albiges-Rizo C. J Cell Biol. 2008 Jan 28; 180(2):427-41.

[J Cell Biol. 2008]
Genetic analysis of beta1 integrin "activation motifs" in mice.
Czuchra A, Meyer H, Legate KR, Brakebusch C, Fässler R. J Cell Biol. 2006 Sep 11; 174(6):889-99. Epub 2006 Sep 5.

[J Cell Biol. 2006]
» See all...

Recent Activity

Clear Turn Off Turn On

Structure and function of the platelet integrin alphaIIbbeta3.Structure and function of the platelet integrin alphaIIbbeta3.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

Structure and function of the platelet integrin alphaIIbbeta3.

Related articles

Cited by 5 PubMed Central articles

Recent Activity