Altern Ther Health Med. 2005 Nov-Dec;11(6):30-4.

Glucomannan and obesity: a critical review.

Source

Rush University College of Nursing, Chicago, Ill, USA.

Abstract

Glucomannan (GM) is a soluble, fermentable, and highly viscous dietary fiber derived from the root of the elephant yam or konjac plant, which is native to Asia. Preliminary evidence suggests that GM may promote weight loss. This review summarizes studies using GM for weight loss as well as studies investigating its mechanisms of action. At doses of 2-4 g per day, GM was well-tolerated and resulted in significant weight loss in overweight and obese individuals. There is some evidence that GM exerts its beneficial effects by promoting satiety and fecal energy loss. Additionally, GM has been shown to improve lipid and lipoprotein parameters and glycemic status. Further investigation of safety, efficacy, and mechanisms of action is needed to determine whether GM can help to decrease the high prevalence of overweight and obesity in the United States.

PMID:: 16320857; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Effect of glucomannan on obese patients: a clinical study. [Int J Obes. 1984]
Effect of glucomannan on obese patients: a clinical study.
Walsh DE, Yaghoubian V, Behforooz A. Int J Obes. 1984; 8(4):289-93.
Review Role of metformin for weight management in patients without type 2 diabetes. [Ann Pharmacother. 2008]
Review Role of metformin for weight management in patients without type 2 diabetes.
Desilets AR, Dhakal-Karki S, Dunican KC. Ann Pharmacother. 2008 Jun; 42(6):817-26. Epub 2008 May 13.
[Pharmacological therapy of obesity]. [G Ital Cardiol (Rome). 2008]
[Pharmacological therapy of obesity].
Pagotto U, Vanuzzo D, Vicennati V, Pasquali R. G Ital Cardiol (Rome). 2008 Apr; 9(4 Suppl 1):83S-93S.
[Chronic use of glucomannan in the dietary treatment of severe obesity]. [Minerva Med. 1992]
[Chronic use of glucomannan in the dietary treatment of severe obesity].
Vita PM, Restelli A, Caspani P, Klinger R. Minerva Med. 1992 Mar; 83(3):135-9.
Review [Glucomannan: properties and therapeutic applications]. [Nutr Hosp. 2004]
Review [Glucomannan: properties and therapeutic applications].
González Canga A, Fernández Martínez N, Sahagún AM, García Vieitez JJ, Díez Liébana MJ, Calle Pardo AP, Castro Robles LJ, Sierra Vega M. Nutr Hosp. 2004 Jan-Feb; 19(1):45-50.

See reviews... See all...

Cited by 2 PubMed Central articles

The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J mice. [Obesity (Silver Spring). 2010]
The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J mice.
Smith DL Jr, Nagy TR, Wilson LS, Dong S, Barnes S, Allison DB. Obesity (Silver Spring). 2010 May; 18(5):995-9. Epub 2009 Oct 1.
Review Should weight-loss supplements be used for pediatric obesity? [Can Fam Physician. 2009]
Review Should weight-loss supplements be used for pediatric obesity?
Rogovik AL, Goldman RD. Can Fam Physician. 2009 Mar; 55(3):257-9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Glucomannan and obesity: a critical review.
Glucomannan and obesity: a critical review.
Altern Ther Health Med. 2005 Nov-Dec ;11(6):30-4.

PubMed
Enzyme immobilization in porous silicon: quantitative analysis of the kinetic pa...
Enzyme immobilization in porous silicon: quantitative analysis of the kinetic parameters for glutathione-S-transferases.
Anal Chem. 2005 Apr 1 ;77(7):1950-6.

PubMed
Role of decreased levels of Fis histone-like protein in Crohn's disease-associat...
Role of decreased levels of Fis histone-like protein in Crohn's disease-associated adherent invasive Escherichia coli LF82 bacteria interacting with intestinal epithelial cells.
J Bacteriol. 2010 Apr ;192(7):1832-43. Epub 2010 Jan 29 .

PubMed
The application of medium-chain fatty acids: edible oil with a suppressing effec...
The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation.
Asia Pac J Clin Nutr. 2008 ;17 Suppl 1:320-3.

PubMed
Determination of Salvinorin A in body fluids by high performance liquid chromato...
Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization.
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25 ;818(2):221-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: