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Nature. 2005 Dec 1;438(7068):578-80.

Membranes are more mosaic than fluid.

Author information

  • Department of Molecular Biophysics and Biochemistry, Yale University, Box 208114, New Haven, Connecticut 06520-8114, USA. don@mail.csb.yale.edu


The wealth of new data on membrane protein structures and functions is changing our general view of membrane architecture. Some of the key themes that are emerging are that membranes are patchy, with segregated regions of structure and function, that lipid regions vary in thickness and composition, and that crowding and ectodomains limit exposure of lipid to the adjacent aqueous regions.

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