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    J Perinat Med. 2005;33(6):561-3.

    Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin.

    Matsuda H, Sakaguchi K, Shibasaki T, Takahashi H, Kawakami Y, Furuya K.

    Source

    Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama Prefecture, Japan. hmatsuda@ndmc.ac.jp

    Abstract

    Parvovirus B19-infected hydrops fetalis was treated using gammaglobulin injection into the peritoneal cavity (GIFPeC) with B19-IgG-rich immunoglobulin. Fetal anemia and hydrops resolved, and B19-DNA in fetal ascites decreased despite no change in maternal B19-IgG or B19-DNA. Gammaglobulin injection into the peritoneal cavity is thus useful for treating hydrops fetalis while avoiding intrauterine blood-transfusion risks.

    PMID:
    16318623
    [PubMed - indexed for MEDLINE]

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      Cited by 3 PubMed Central articles

      • Parvovirus B19 - Revised. [Transfus Med Hemother. 2010]
        Parvovirus B19 - Revised.
        Blümel J, Burger R, Drosten C, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Montag-Lessing T, Offergeld R, et al. Transfus Med Hemother. 2010; 37(6):339-350. Epub 2010 Nov 17.
      • Fetal intraperitoneal injection of immunoglobulin diminishes alloimmune hemolysis. [J Perinatol. 2011]
        Fetal intraperitoneal injection of immunoglobulin diminishes alloimmune hemolysis.
        Matsuda H, Yoshida M, Wakamatsu H, Furuya K. J Perinatol. 2011 Apr; 31(4):289-92.
      • Review Parvovirus B19 infection in human pregnancy. [BJOG. 2011]
        Review Parvovirus B19 infection in human pregnancy.
        Lamont RF, Sobel JD, Vaisbuch E, Kusanovic JP, Mazaki-Tovi S, Kim SK, Uldbjerg N, Romero R. BJOG. 2011 Jan; 118(2):175-86. Epub 2010 Oct 13.

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