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Spinal Cord. 2006 Jul;44(7):421-6. Epub 2005 Nov 29.

Secondary degeneration reduced by inosine after spinal cord injury in rats.

Author information

  • 1Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China.

Abstract

STUDY DESIGN:

Assessment of the potential protective effects of inosine on an animal model of spinal cord injury.

OBJECTIVES:

Our previous studies have demonstrated that inosine can directly protect neurons in vitro from zinc-induced injury and axotomized retinal ganglion cells of rats in vivo. This investigation was carried out to examine the possible protective effects of inosine on spinal cord secondary degeneration.

SETTING:

Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China.

METHODS:

Compressive spinal cord injury (95-g load for 1 min) model was established in rats, and inosine was administrated beginning at different time points (2, 12, or 24 h) after spinal cord injury.

RESULTS:

Using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) technique and hematoxylin and eosin staining, our study demonstrated that administration of inosine as late as 12 h after injury significantly reduced the total volume of spinal cord degenerative areas and the number of apoptotic cells 3 days following the trauma.

CONCLUSION:

Inosine can significantly reduce the spread of secondary degeneration and the cell death following spinal cord injury in adult rats. These findings may find a clinical application in the treatment of acute spinal cord injury.

PMID:
16317421
[PubMed - indexed for MEDLINE]
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