Cloning of the gamma chain of the human IL-2 recep...[Science. 1992]

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1: Science. 1992 Jul 17;257(5068):379-82. Links

Cloning of the gamma chain of the human IL-2 receptor.

Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K.

Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.

A third subunit, the gamma chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The gamma chain is necessary for the formation of the high- and intermediate-affinity receptors, which consists of alpha beta gamma heterotrimers and beta gamma heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the gamma chain is present; alpha and beta are insufficient for internalization. Thus, the gamma chain is an indispensable component of the functional IL-2R.

PMID: 1631559 [PubMed - indexed for MEDLINE]

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