Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann Neurol. 2005 Dec;58(6):939-45.

Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis.

Author information

  • 1Department of Neurology, Vanderbilt Medical Center, Nashville, TN 37212, USA. subramaniam.sriram@vanderbilt.edu

Abstract

Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines critically the validity that EAE is an adequate and useful animal model of MS and finds credible evidence lacking. EAE represents more a model of acute central nervous system inflammation than the counterpart of MS. We propose to reconsider the utilization of EAE, especially when this model is used to define therapy. This will also force us to examine MS without the restraints imposed by EAE, as to what it is, rather than what it looks like.

PMID:
16315280
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk