Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5951-5.

Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.

Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K.

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Biological Computation Research Department, AT&T Bell Laboratories, Murray Hill, NJ 07974.

Abstract

We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T*2. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.

PMID:: 1631079; [PubMed - indexed for MEDLINE]
PMCID:: PMC402116

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