New 1,3,4-thiadiazole derivatives endowed with ana...[Bioorg Med Chem. 2006]

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1: Bioorg Med Chem. 2006 Mar 15;14(6):1698-705. Epub 2005 Nov 28. Links

New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.

Schenone S, Brullo C, Bruno O, Bondavalli F, Ranise A, Filippelli W, Rinaldi B, Capuano A, Falcone G.

Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3-16132 Genoa, Italy. schensil@unige.it

Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.

PMID: 16310359 [PubMed - indexed for MEDLINE]

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New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities.

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