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1: Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. Epub 2005 Nov 23.Click here to read Links

Androstenediol analogs as ER-beta-selective SERMs.

Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Sharma N, Fitzgerald PM, Rohrer SP, Hammond ML.

Merck Research Laboratories, PO Box 2000, Rahway NJ 07065, USA. tim_blizzard@merck.com

A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.

PMID: 16309907 [PubMed - indexed for MEDLINE]

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