Cell Tissue Bank. 2005;6(4):255-62.

Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acid.

Strong DM, Nelson K, Pierce M, Stramer SL.

Source

Puget Sound Blood Center/Northwest Tissue Center, 921 Terry Avenue Seattle, WA, 98104, USA. dmstrong@psbc.org

Abstract

Nucleic acid testing (NAT) has reduced the risk of transmitting infectious disease through blood transfusion. Currently NAT for HIV-1 and HCV are FDA licensed and performed by nearly all blood collection facilities, but HBV NAT is performed under an investigational study protocol. Residual risk estimates indicate that NAT could potentially reduce disease transmission through transplanted tissue. However, tissue donor samples obtained post-mortem have the potential to produce an invalid NAT result due to inhibition of amplification reactions by hemolysis and other factors. The studies reported here summarize the development of protocols to allow NAT of deceased donor samples with reduced rates of invalid results. Using these protocols, inventories from two tissue centers were tested with greater than 99% of samples producing a valid test result.

PMID:: 16308764; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Effect of viral nucleic acid testing on contamination frequency of manufacturing plasma pools. [Transfusion. 2008]
Effect of viral nucleic acid testing on contamination frequency of manufacturing plasma pools.
Nübling CM, Unkelbach U, Chudy M, Seitz R. Transfusion. 2008 May; 48(5):822-6. Epub 2008 Jan 15.
[Trends in residual risk of transfusion-transmitted viral infections (HIV, HCV, HBV) in France between 1992 and 2002 and impact of viral genome screening (Nucleic Acid Testing)]. [Transfus Clin Biol. 2004]
[Trends in residual risk of transfusion-transmitted viral infections (HIV, HCV, HBV) in France between 1992 and 2002 and impact of viral genome screening (Nucleic Acid Testing)].
Pillonel J, Laperche S, Groupe "Agents Transmissibles par Transfusion" de la Société française de transfusion sanguine, Etablissement français du sang, Centre de transfusion sanguine des armées. Transfus Clin Biol. 2004 Apr; 11(2):81-6.
Sensitivity of two hepatitis B virus, hepatitis C virus (HCV), and human immunodeficiency virus (HIV) nucleic acid test systems relative to hepatitis B surface antigen, anti-HCV, anti-HIV, and p24/anti-HIV combination assays in seroconversion panels. [Transfusion. 2009]
Sensitivity of two hepatitis B virus, hepatitis C virus (HCV), and human immunodeficiency virus (HIV) nucleic acid test systems relative to hepatitis B surface antigen, anti-HCV, anti-HIV, and p24/anti-HIV combination assays in seroconversion panels.
Assal A, Barlet V, Deschaseaux M, Dupont I, Gallian P, Guitton C, Morel P, van Drimmelen H, David B, Lelie N, et al. Transfusion. 2009 Feb; 49(2):301-10.
Review Tissue donation and virus safety: more nucleic acid amplification testing is needed. [Transpl Infect Dis. 2010]
Review Tissue donation and virus safety: more nucleic acid amplification testing is needed.
Pruss A, Caspari G, Krüger DH, Blümel J, Nübling CM, Gürtler L, Gerlich WH. Transpl Infect Dis. 2010 Oct; 12(5):375-86.
Review Nucleic acid testing: update and applications. [Semin Hematol. 2001]
Review Nucleic acid testing: update and applications.
Benjamin RJ. Semin Hematol. 2001 Oct; 38(4 Suppl 9):11-6.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Preventing disease transmission by deceased tissue donors by testing blood for v...
Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acid.
Cell Tissue Bank. 2005 ;6(4):255-62.

PubMed
Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Myc...
Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis.
Mol Microbiol. 2003 May ;48(3):833-43.

PubMed
Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro an...
Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum.
J Med Food. 2010 Apr ;13(2):460-8.

PubMed
Combined use of hyperthermia and radiation therapy for treating locally advanced...
Combined use of hyperthermia and radiation therapy for treating locally advanced cervix carcinoma.
Cochrane Database Syst Rev. 2010 Mar 17 ;(3):CD006377.

PubMed
Usefulness of cardiorespiratory fitness to predict coronary heart disease risk i...
Usefulness of cardiorespiratory fitness to predict coronary heart disease risk independent of physical activity.
Am J Cardiol. 2010 Jul 15 ;106(2):210-5. Epub 2010 Jun 10 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acid.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information