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Eur J Clin Nutr. 2006 Apr;60(4):443-54.

Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants.

Author information

  • 1Institut de Recherche pour le Développement (IRD), UR 106 Nutrition, Alimentation, Sociétés, Montpellier Cedex, France. j.berger@fpt.vn

Abstract

OBJECTIVE:

To evaluate the effect of combined iron-zinc supplementation on micronutrient status, growth and morbidity.

DESIGN:

Randomized, double-masked, placebo-controlled supplementation trial.

SETTING:

Rural district of Que Vo, in the Red River Delta in Vietnam.

SUBJECTS:

A total of 915 breast-fed infants aged 4-7 months were included and 784 completed the study.

INTERVENTIONS:

The Fe-group received daily and for a 6-month period 10 mg of iron, the Zn-group 10 mg zinc, the Fe-Zn group 10 mg iron+10 mg zinc and the placebo group a placebo. Hemoglobin (Hb), serum ferritin (SF) and zinc (SZn), and anthropometry were measured before and at the end of the intervention. Morbidity was recorded daily.

RESULTS:

Changes of Hb and SF were higher in both Fe and Fe+Zn groups (respectively 22.6 and 20.6 g/l for Hb; 36.0 and 24.8 microg/l for SF) compared to Zn and placebo groups (Hb: 6.4 and 9.8 g/l; SF: -18.2 and -16.9 microg/l, P<0.0001). SZn increased more in Zn group (10.3 micromol/l) than in Fe+Zn group (8.0 micromol/l, P=0.03) and more in these groups compared to Fe and placebo groups (1.6 and 1.2 micromol/l, P<0.0001). Weight gain was higher in the Zn group. No significant effects of supplementations on growth in length or morbidity.

CONCLUSIONS:

Combined iron-zinc supplementation had a positive effect on iron and zinc status in infants. However, the positive effect of zinc alone on SZn and weight would indicate a negative interaction of iron when added to zinc supplements.

SPONSORSHIP:

UNICEF New York.

PMID:
16306925
[PubMed - indexed for MEDLINE]
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