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1: Antimicrob Agents Chemother. 2005 Dec;49(12):5185-8.Click here to read Click here to read Links

Human immunodeficiency virus type 1 latency model for high-throughput screening.

Micheva-Viteva S, Pacchia AL, Ron Y, Peltz SW, Dougherty JP.

Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA.

Human immunodeficiency virus type 1 (HIV-1) is not eliminated from patients even after years of antiretroviral therapy, apparently due to the presence of latently infected cells. Here we describe the development of a cell-based system of latency that can be used for high-throughput screening aimed at novel drug discovery to eradicate HIV-1 infection.

PMID: 16304201 [PubMed - indexed for MEDLINE]

PMCID: PMC1315948