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J Coll Physicians Surg Pak. 2005 Nov;15(11):683-5.

The efficacy of local infiltration of triamcinolone acetonide with lignocaine compared with lignocaine alone in the treatment of postherpetic neuralgia.

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  • 1Department of Dermatology, Combined Military Hospital, Peshawar. amjads59@hotmail.com

Abstract

OBJECTIVE:

To assess the efficacy of local infiltration of corticosteroid with lignocaine compared to lignocaine alone in the treatment of postherpetic neuralgia.

DESIGN:

A randomized clinical trial.

PLACE AND DURATION OF STUDY:

The Skin Department, Military Hospital, Rawalpindi from September 2002 to March 2003.

PATIENTS AND METHODS:

Sixty patients were selected for the study. They were randomly assigned to two groups. Group-I received injection triamcinolone acetonide with lignocaine and group-II was given injection lignocaine alone. Three injections were given to each patient at fortnightly interval and pain relief was assessed by visual analogue scale at 6 and 12 weeks following the first injection.

RESULTS:

Follow-up at 6 weeks showed complete pain relief in 63.3% (n=19) patients of group-I in comparison to 16.6% (n=5) of group-II. Chi-square value was 13.3 (p<0.001). At 12 weeks follow-up group-I showed further improvement with complete pain relief in 83.3% (n=25) whereas group-II showed diminishing response with cure rates falling to 6.6% (n=2). Chi-square value was 35.6 (p<0.001).

CONCLUSION:

Locally infiltrated injection triamcinolone acetonide with lignocaine was significantly more effective than injection lignocaine alone in the treatment of postherpetic neuralgia both at 6 and 12 weeks follow-up.

[PubMed - indexed for MEDLINE]
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