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Respiration. 2008;75(2):211-4. Epub 2005 Nov 15.

Successful treatment of sarcoidosis-associated pulmonary hypertension with bosentan.

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  • 1Division of Pulmonary/Critical Care Medicine, University of Connecticut School of Medicine, Farmington, Conn., USA.


Sarcoidosis is a systemic granulomatous disease of unknown etiology, in which the lungs and intrathoracic lymph nodes are predominant sites of involvement. Pulmonary hypertension is a known complication of sarcoidosis. Treatment of sarcoidosis-associated pulmonary hypertension has traditionally focused on the initiation of systemic corticosteroids, but has had inconsistent results. We present a patient with sarcoidosis-associated pulmonary hypertension who achieved substantial clinical improvement with the dual endothelin receptor antagonist bosentan.

Copyright (c) 2008 S. Karger AG, Basel

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