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Expert Rev Med Devices. 2005 Mar;2(2):175-89.

Improving the lives of patients with medically refractory epilepsy by electrical stimulation of the nervous system.

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  • 1Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA.


Vagal nerve stimulation proved effective in animal models of epilepsy, and in open and double-blinded trials, in over 450 patients. Seizure reduction improved for at least 2 years. Almost 50% of treated patients achieve at least a 50% reduction in seizure frequency. Other advantages include termination of a seizure and improved alertness. Benefits were demonstrated in children, partial and generalized epilepsies, and in specific neurologic syndromes.

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