Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Gastroenterol Hepatol. 2005 Dec;17(12):1299-303.

Oral tolerance: lessons on treatment of food allergy.

Author information

  • 1Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA.


Oral tolerance is the active non-response by the immune system to an antigen administered through the oral route. It is postulated that food hypersensitivity results from a breakdown in oral tolerance induction, and the importance of oral tolerance in food hypersensitivity can be traced back to classic experiments from 1911 in which guinea pigs were protected from anaphylaxis by prior feeding of antigen. Host and antigenic factors play a role in determining the pathways and mechanisms to which a fed antigen can gain tolerance. Recent studies have demonstrated the potential of using oral tolerance to treat food allergies, and additional studies are necessary to further our understanding of mechanisms of oral tolerance induction.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk