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J Bacteriol. 2005 Dec;187(23):8216-20.

Identification of regions involved in enzymatic stability of peptide deformylase of Mycobacterium tuberculosis.

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  • 1Institute of Microbial Technology, Chandigarh, India.

Abstract

Sequence analysis of peptide deformylase of Mycobacterium tuberculosis revealed the presence of insertions (residues 74 to 85) and an unusually long carboxy-terminal end (residues 182 to 197). Our results with deletion mutants indicated the contribution of these regions in maintaining enzymatic stability. Furthermore, we showed that the region spanning the insertions was responsible for maintaining resistance to oxidizing agents, like H(2)O(2).

PMID:
16291698
[PubMed - indexed for MEDLINE]
PMCID:
PMC1291256
Free PMC Article

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