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Genes Dev. 2005 Nov 15;19(22):2645-55.

Bacterial outer membrane vesicles and the host-pathogen interaction.

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  • 1Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA. meta.kuehn@duke.edu

Abstract

Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.

PMID:
16291643
[PubMed - indexed for MEDLINE]
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