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    Bioorg Med Chem Lett. 2006 Feb;16(3):581-3. Epub 2005 Nov 8.

    Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.

    Awale S, Nakashima EM, Kalauni SK, Tezuka Y, Kurashima Y, Lu J, Esumi H, Kadota S.

    Source

    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

    Abstract

    The CH(2)Cl(2)-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 microg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 microg/ml.

    PMID:
    16288865
    [PubMed - indexed for MEDLINE]

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