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Nat Med. 2005 Dec;11(12):1290-2. Epub 2005 Nov 20.

AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.

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  • 1Laboratory of Genomic Diversity, NCI-Frederick, Basic Research Program, SAIC Frederick, P.O. Box B, Frederick, Maryland 21702, USA.


An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

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