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The KCNQ1 potassium channel: from gene to physiological function.
Department of Medical Physiology, University of Copenhagen, Denmark.
The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.
PMID: 16287990 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes.
Mruk K, Kobertz WR.
PLoS One. 2009; 4(1):e4236. Epub 2009 Jan 21.
[PLoS One. 2009]
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Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.
Kang C, Tian C, Sönnichsen FD, Smith JA, Meiler J, George AL Jr, Vanoye CG, Kim HJ, Sanders CR.
Biochemistry. 2008 Aug 5; 47(31):7999-8006. Epub 2008 Jul 9.
[Biochemistry. 2008]
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Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations.
Jackson HA, Accili EA.
BMC Evol Biol. 2008 Jun 30; 8:188. Epub 2008 Jun 30.
[BMC Evol Biol. 2008]
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Patient Drug Information
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Potassium (Glu-K® , K+ 10® , K+ 8® , ...)
Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...