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J Dtsch Dermatol Ges. 2003 Feb;1(2):126-30.

Pemphigoid gestationis: treatment with immunoapheresis.

Author information

  • 1Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, University of Vienna Medical School (AKH Wien), Austria. stefan.woehrl@univie.ac.at

Abstract

BACKGROUND:

Pemphigoid (herpes) gestationis is a rare blistering disease of pregnancy. Topical and systemic corticosteroids and antihistamines are usually sufficient for treatment.

CASE REPORT:

A patient suffering from severe, therapy-resistant pemphigoid gestationis was successfully treated with the additional use of six sessions of immunoapheresis. Systemic corticosteroids could be tapered and serum autoantibody levels to bullous pemphigoid antigen 2 (BPAG2 = BP180) significantly dropped during this treatment.

CONCLUSION:

Immunoapheresis represents a helpful therapeutic option with few side effects for severe cases of pemphigoid gestationis, unresponsive to conventional treatment.

PMID:
16285180
[PubMed - indexed for MEDLINE]
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