-
Structure of a V3-containing HIV-1 gp120 core.
Huang CC,
Tang M,
Zhang MY,
Majeed S,
Montabana E,
Stanfield RL,
Dimitrov DS,
Korber B,
Sodroski J,
Wilson IA,
Wyatt R,
Kwong PD.
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
PMID: 16284180 [PubMed - indexed for MEDLINE]
PMCID: PMC2408531
-
Cited by 68 PubMed Central articles
-
Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site.
Dey B, Svehla K, Xu L, Wycuff D, Zhou T, Voss G, Phogat A, Chakrabarti BK, Li Y, Shaw G, et al.
PLoS Pathog. 2009 May; 5(5):e1000445. Epub 2009 May 29.
[PLoS Pathog. 2009]
-
Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China.
Ma L, Guo Y, Yuan L, Huang Y, Sun J, Qu S, Yu X, Meng Z, He X, Jiang S, et al.
Retrovirology. 2009 May 14; 6:45. Epub 2009 May 14.
[Retrovirology. 2009]
-
Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus.
Simon-Loriere E, Galetto R, Hamoudi M, Archer J, Lefeuvre P, Martin DP, Robertson DL, Negroni M.
PLoS Pathog. 2009 May; 5(5):e1000418. Epub 2009 May 8.
[PLoS Pathog. 2009]
- » See all...
Structures reported by this article