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Genome Biol. 2005;6(11):237. Epub 2005 Oct 19.

Close encounters between active genes in the nucleus.

Author information

  • 1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Abstract

A recent paper demonstrates that coregulated genes on different chromosomes show surprisingly high frequencies of colocalization within the nucleus; this complements similar results found previously for genes localized tens of megabases apart on a single chromosome. Colocalization could be related to the earlier observation of active genes associating with foci where RNA polymerase II is concentrated.

PMID:
16277755
[PubMed - indexed for MEDLINE]
PMCID:
PMC1297641
Free PMC Article

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