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1: Genome Biol. 2005;6(11):237. Epub 2005 Oct 19.Click here to read Click here to read Links

Close encounters between active genes in the nucleus.

Chuang CH, Belmont AS.

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

A recent paper demonstrates that coregulated genes on different chromosomes show surprisingly high frequencies of colocalization within the nucleus; this complements similar results found previously for genes localized tens of megabases apart on a single chromosome. Colocalization could be related to the earlier observation of active genes associating with foci where RNA polymerase II is concentrated.

PMID: 16277755 [PubMed - indexed for MEDLINE]

PMCID: PMC1297641