Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Genome Biol. 2005;6(11):R95. Epub 2005 Oct 17.

A computational investigation of kinetoplastid trans-splicing.

Author information

  • 1Laboratory of Computational Genomics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. sxgsbi@rit.edu


Trans-splicing is an unusual process in which two separate RNA strands are spliced together to yield a mature mRNA. We present a novel computational approach which has an overall accuracy of 82% and can predict 92% of known trans-splicing sites. We have applied our method to chromosomes 1 and 3 of Leishmania major, with high-confidence predictions for 85% and 88% of annotated genes respectively. We suggest some extensions of our method to other systems.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk