Dipeptidyl peptidase IV activity and/or structure ...[Arthritis Res Ther. 2005]

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1: Arthritis Res Ther. 2005;7(6):253-69. Epub 2005 Oct 26. Links

Dipeptidyl peptidase IV activity and/or structure homologs: contributing factors in the pathogenesis of rheumatoid arthritis?

Sedo A, Duke-Cohan JS, Balaziova E, Sedova LR.

Laboratory of Cancer Cell Biology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. Aleksi@mbox.cesnet.cz

Several of the proinflammatory peptides involved in rheumatoid arthritis pathogenesis, including peptides induced downstream of tumor necrosis factor-alpha as well as the monocyte/T cell-attracting chemokines RANTES and stromal cell-derived factor (SDF)-1alpha and the neuropeptides vasoactive intestinal peptide (VIP) and substance P, have their biological half-lives controlled by dipeptidyl peptidase IV (DPPIV). Proteolysis by DPPIV regulates not only the half-life but also receptor preference and downstream signaling. In this article, we examine the role of DPPIV homologs, including CD26, the canonical DPPIV, and their substrates in the pathogenesis of rheumatoid arthritis. The differing specific activities of the DPPIV family members and their differential inhibitor response provide new insights into therapeutic design.

PMID: 16277701 [PubMed - indexed for MEDLINE]

PMCID: PMC1297595

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Verh K Acad Geneeskd Belg. 2001; 63(1):5-32; discussion 32-3.

[Verh K Acad Geneeskd Belg. 2001]
Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma.
Int J Cancer. 2004 Jul 10; 110(5):652-9.

[Int J Cancer. 2004]
Circulating CD26 is negatively associated with inflammation in human and experimental arthritis.
Am J Pathol. 2005 Feb; 166(2):433-42.

[Am J Pathol. 2005]
Dipeptidyl peptidase-IV activity and/or structure homologs (DASH): contributing factors in the pathogenesis of rheumatic diseases?
Adv Exp Med Biol. 2006; 575:169-74.

[Adv Exp Med Biol. 2006]
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[Regul Pept. 1999]
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