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Cytogenet Genome Res. 2006;112(1-2):6-10.

7E olfactory receptor gene clusters and evolutionary chromosome rearrangements.

Author information

  • 1Institute for Human Genetics, Mainz University School of Medicine, Mainz, Germany.

Abstract

Olfactory receptor (OR) genes of the 7E subfamily have been duplicated to multiple regions throughout the human genome. Segmental duplications containing 7E OR genes have been associated with both pathological and evolutionary chromosome rearrangements. Many of these breakpoint regions coincide with breaks of chromosomal synteny in the mouse, rat and/or chicken genomes. Collectively, these data suggest that 7E OR-containing regions represent hot spots of genomic instability.

Copyright 2006 S. Karger AG, Basel.

PMID:
16276084
[PubMed - indexed for MEDLINE]
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